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Product Name
ULK1 antibody
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Description
ULK1 Rabbit Polyclonal antibody. Positive WB detected in rat skeletal muscle tissue. Positive IHC detected in human skeletal muscle tissue, human liver tissue. Observed molecular weight by Western-blot: 150 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
ATG1 antibody; FLJ38455 antibody; FLJ46475 antibody; KIAA0722 antibody; ULK1 antibody; Unc 51 like kinase 1 antibody; UNC51 antibody; Unc51.1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_003565). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:50-1:500
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Validations
rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:116568(ULK1 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:116568(ULK1 Antibody) at dilution of 1:200 (under 10x lens).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:116568(ULK1 Antibody) at dilution of 1:200 (under 40x lens).
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Background
ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200)(PMID:21460634). ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC(PMID:23573318).
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