-
Product Name
TWIST2 antibody
- Documents
-
Description
TWIST2 Rabbit Polyclonal antibody. Positive WB detected in NIH/3T3 cells, MCF7 cells, mouse liver tissue. Observed molecular weight by Western-blot: 21kDa, 60 kDa
-
Tested applications
ELISA, WB
-
Species reactivity
Human, Mouse; other species not tested.
-
Alternative names
bHLHa39 antibody; Dermis expressed protein 1 antibody; Dermo 1 antibody; DERMO1 antibody; twist homolog 2 (Drosophila) antibody; Twist related protein 2 antibody; TWIST2 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of TWIST2 recombinant protein (Accession Number: NM_001271893). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
-
Validations
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116503(TWIST2 antibody) at dilution of 1:500
-
Background
TWIST2, also named as BHLHA39 and DERMO1,is a basic helix-loop-helix protein which acts as a transcriptional regulator, plays a central role in differentiation of mesodermal during embryogenesis. TWIST2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. It is also implicated in tumorigenesis, invasion and metastasis. TWIST2 forms both homodimers(45KD) and heterodimers with E2A E proteins, and dimer partner selection is a critical mediator of TWIST function. (PMID:14724576, 16502419). The protein sequence of TWIST1 and TWIST2 is very similar. This antibody can recognize both TWIST1(~28kd), TWIST2 (22kd) and the Dimer form (45-60kd).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"