TUSC2 antibody

TUSC2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TUSC2 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue, human colon cancer tissue. Positive IF detected in A549 cells. Positive WB detected in human heart tissue, mouse pancreas tissue. Observed molecular weight by Western-blot: 10-12kd

ELISA, WB, IHC, IF

Human,Mouse,Rat; other species not tested.

C3orf11 antibody; Fus 1 protein antibody; FUS1 antibody; Fusion 1 protein antibody; LGCC antibody; PAP antibody; PDAP2 antibody; PDGFA assOCiated protein 2 antibody; tumor suppressor candidate 2 antibody; TUSC2 antibody

Rabbit IgG

This antibody was obtained by immunization of TUSC2 recombinant protein (Accession Number: NM_007275). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

FUS1 (or TUSC2) gene is a highly conserved lung cancer candidate gene, which was identified in the 120 kb 3p21.3 critical region contained in nested lung and breast cancer homozygous deletions. Overexpression of FUS1 gene leads to G1 arrest and growth inhibition of lung cancer cells (PMID: 11593436). The encoded Fusion-1 protein was down-regulated, mutated or lost in the majority of inflammatory thoracic malignancies. It has been evidenced that Fusion-1 establishes its immune- and tumour-suppressive activities via regulation of mitochondrial homeostasis (PMID: 22513871). In addition, myristoylation is found to be required for Fusion-1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer and a role for deficient posttranslational modification in tumor suppressor-gene-mediated carcinogenesis (PMID: 15126327).