TRIM5 antibody

Cat.#: 116319

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Product Information

  • Product Name
    TRIM5 antibody
  • Documents
  • Description
    TRIM5 Rabbit Polyclonal antibody. Positive WB detected in MKN-45 cells, mouse stomach tissue. Positive IHC detected in human prostate cancer tissue, human stomach tissue. Observed molecular weight by Western-blot: 46 kDa, 70 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    RING finger protein 88 antibody; RNF88 antibody; TRIM5 antibody; TRIM5alpha antibody; tripartite motif containing 5 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TRIM5 recombinant protein (Accession Number: NM_033092). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:116319(TRIM5 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:116319(TRIM5 antibody) at dilution of 1:50 (under 10x lens)

    MKN-45 cells were subjected to SDS PAGE followed by western blot with Catalog No:116319(TRIM5 Antibody) at dilution of 1:300

    MKN-45 cells were subjected to SDS PAGE followed by western blot with Catalog No:116319(TRIM5 Antibody) at dilution of 1:300

  • Background
    TRIM5 belongs to the large tripartite motif protein family, members of which typically are composed of 3 zinc-binding domains, a RING, unique B-box type 1 and B-box type 2 domains, followed by a coiled-coil (CC) region. TRIM proteins use homomultimerization to identify specific cell compartments. TRIM5 promotes innate immune signaling and that this activity is amplified by retroviral infection and interaction with the capsid lattice. TRIM5 has 6 variants termed alpha, beta, gamma, delta, epsilon, and iota with the MW of 56 kDa, 46 kDa, 40 kDa, 37 kDa, 31 kDa and 29 kDa. TRIM5 can form homodimers (~70 kDa) and homotrimers (90-160 kDa).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"