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Product Name
TRIM29 antibody
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Description
TRIM29 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, A431 cells. Positive IHC detected in human testis tissue, human skin tissue. Observed molecular weight by Western-blot: 65kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ATDC antibody; FLJ36085 antibody; TRIM29 antibody; tripartite motif containing 29 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TRIM29 recombinant protein (Accession Number: NM_012101). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:116309(TRIM29 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human testis using Catalog No:116309(TRIM29 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human testis using Catalog No:116309(TRIM29 antibody) at dilution of 1:100 (under 40x lens)
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Background
TRIM29(Tripartite motif-containing protein 29) is also named as ATDC( Ataxia telangiectasia group D-associated protein).ATDC protein physically interacted with the intermediate filament protein vimentin, a protein kinase C substrate and colocalizing protein, and with an inhibitor of protein kinase C, PKCI1(PMID:7644499).ATDC gene is highly expressed in samples of primary pancreatic cancer and PanIN lesions compared to normal pancreas and chronic pancreatitis and the highly expressed protein in human pancreatic cancer,enhances cancer cell proliferation and in vivo tumorigenicity by upregulation of the Wnt/b-Catenin signaling pathway(Wang, L. etc.2007).
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References
- Tang ZP, Dong QZ, Cui QZ, Papavassiliou P, Wang ED, Wang EH. Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. PloS one. 8(6):e63676. 2013.
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