TRAF3 antibody

TRAF3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TRAF3 Rabbit Polyclonal antibody. Positive IP detected in Raji cells. Positive WB detected in HEK-293 cells, COLO 320 cells, HeLa cells, Raji cells. Observed molecular weight by Western-blot: 55-60 kDa

ELISA, IP, WB

Human,Mouse,Rat; other species not tested.

CAP 1 antibody; CAP1 antibody; CD40 binding protein antibody; CD40bp antibody; CRAF1 antibody; LAP1 antibody; LMP1 assOCiated protein 1 antibody; TRAF3 antibody

Rabbit IgG

This antibody was obtained by immunization of TRAF3 recombinant protein (Accession Number: XM_017021618). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TNF receptor-associated factor 3 (TRAF3) has many alternative names including CAP-1, CD40 receptor-associated factor 1(CRAF1), CD40-binding protein(CD40BP) and LMP1-associated protein 1 (LAP1). TRAF3 regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of innate immune response. It modulates signaling pathways leading to the production of cytokines and interferon. As an essential constituent of several E3 ubiquitin-protein ligase complexes, TRAF3 promote 'Lys-63'-linked ubiquitination of target proteins. Moreover, TRAF3 undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to various stimuli and is deubiquitinated by OTUB1, OTUB2 and OTUD5.

• Chen HW, Yang YK, Xu H, Yang WW, Zhai ZH, Chen DY. Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6. Scientific reports. 5:14770. 2015.