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Product Name
TMPRSS4 antibody
- Documents
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Description
TMPRSS4 Rabbit Polyclonal antibody. Positive WB detected in SW 1990 cells, BxPC-3 cells, mouse stomach tissue. Positive IHC detected in human pancreas cancer tissue, human colon cancer tissue, human colon tissue, human stomach cancer tissue. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
CAPH2 antibody; Channel activating protease 2 antibody; MT SP2 antibody; TMPRSS3 antibody; TMPRSS4 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TMPRSS4 recombinant protein (Accession Number: NM_019894). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:116276(TMPRSS4 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:116276(TMPRSS4 antibody) at dilution of 1:50 (under 40x lens)
SW 1990 cells were subjected to SDS PAGE followed by western blot with Catalog No:116276(TMPRSS4 Antibody) at dilution of 1:1000
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Background
TMPRSS4, also named as CAPH2 and MT-SP2, belongs to the peptidase S1 family. TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues. It promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition(EMT)(PMID:20118200).
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References
- Li T, Zeng ZC, Wang L. Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition. Cancer gene therapy. 18(9):617-26. 2011.
- Jia JB, Wang WQ, Sun HC. A novel tripeptide, tyroserleutide, inhibits irradiation-induced invasiveness and metastasis of hepatocellular carcinoma in nude mice. Investigational new drugs. 29(5):861-72. 2011.
- Liang B, Wu M, Bu Y, Zhao A, Xie F. Prognostic value of TMPRSS4 expression in patients with breast cancer. Medical oncology (Northwood, London, England). 30(2):497. 2013.
- Cheng D, Kong H, Li Y. TMPRSS4 as a poor prognostic factor for triple-negative breast cancer. International journal of molecular sciences. 14(7):14659-68. 2013.
- Luo ZY, Wang YY, Zhao ZS, Li B, Chen JF. The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancer. PloS one. 8(7):e70311. 2013.
- Min HJ, Lee Y, Zhao XF. TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion. Cellular signalling. 26(2):398-408. 2014.
- Cheng D, Liang B, Li Y. High TMPRSS4 expression is a predictor of poor prognosis in cervical squamous cell carcinoma. Cancer epidemiology. 37(6):993-7. 2013.
- Dai W, Zhou Q, Xu Z, Zhang E. Expression of TMPRSS4 in patients with salivary adenoid cystic carcinoma: correlation with clinicopathological features and prognosis. Medical oncology (Northwood, London, England). 30(4):749. 2013.
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