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Product Name
TMEM176B antibody
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Description
TMEM176B Rabbit Polyclonal antibody. Positive IP detected in mouse lung tissue. Positive WB detected in A549 cells, human placenta tissue. Observed molecular weight by Western-blot: 31 kDa, 23 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
FLJ26014 antibody; LR8 antibody; Protein LR8 antibody; TMEM176B antibody; transmembrane protein 176B antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TMEM176B recombinant protein (Accession Number: XM_047420259). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:2000
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:116108(TMEM176B Antibody) at dilution of 1:300
IP Result of anti-TMEM176B (IP:Catalog No:116108, 4ug; Detection:Catalog No:116108 1:500) with mouse lung tissue lysate 4000ug.
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Background
TMEM176B (also known as LR8) is a transmembrane protein belongs to the MS4A family of proteins. It may play a role in the process of maturation of dendritic cells. TMEM176B was first discovered in human lung fibroblasts and is associated with human small cell lung carcinoma. Studies suggest that TMEM176B might be involved in cancer and might serve as targets for antiangiogenic therapy of cancer patients (PMID: 24602018, 22244448). There are two isoforms produced by alternative splicing.
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