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Product Name
TMEM106B antibody
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Description
TMEM106B Mouse Monoclonal antibody. Positive WB detected in U-251 cells. Observed molecular weight by Western-blot: ~40 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
FLJ11273 antibody; TMEM106B antibody; transmembrane protein 106B antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of TMEM106B recombinant protein (Accession Number: NM_001134232). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
U-251 cells were subjected to SDS PAGE followed by western blot with Catalog No:107627(TMEM106B Antibody) at dilution of 1:1000
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Background
TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. TMEM106B can be showed as 31-40kDa and 60-75kDa (Glycosylated or Dimer) form in western blot test.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"