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Product Name
TIN2 antibody
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Description
TIN2 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in mouse spleen tissue. Observed molecular weight by Western-blot: 50 kDa; 40 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
TIN2 antibody; TIN2L antibody; TINF2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TIN2 recombinant protein (Accession Number: NM_001099274). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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Validations
mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:116143(TIN2 antibody) at dilution of 1:200
Immunofluorescent analysis of HepG2 cells, using TINF2 antibody Catalog No:116143 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
TIN2, also named as TINF2, is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. TIN2 has some isoforms with MW 50 kDa (TIN2L), 40 kDa (TIN2S) and 13 kDa. This antibody detects TIN2L, TIN2S and the shelterin complex.
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References
- Uziel O, Yerushalmi R, Zuriano L. BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo. Oncotarget. 7(3):2433-54. 2016.
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