THOC7 antibody

THOC7 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

THOC7 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, HEK-293 cells, HeLa cells, human liver tissue. Positive IHC detected in human kidney tissue, human brain tissue, human lung tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 24 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

FLJ23445 antibody; fSAP24 antibody; hTREX30 antibody; NIF3L1 binding protein 1 antibody; NIF3L1BP1 antibody; THO complex subunit 7 homolog antibody; THOC7 antibody

Rabbit IgG

This antibody was obtained by immunization of TH℃7 recombinant protein (Accession Number: NM_025075). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

THoc7 is a member of the THO complex that associate with the mRNA export apparatus. It is required for efficient export of polyadenylated RNA. It acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

• Sakuma T, Tonne JM, Ikeda Y. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Viruses. 6(3):1135-48. 2014.