THOC1 antibody

THOC1 antibody

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• Material Safety Data Sheets (MSDS)

THOC1 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 84 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

HPR1 antibody; hTREX84 antibody; Nuclear matrix protein p84 antibody; P84 antibody; P84N5 antibody; THO complex 1 antibody; THO complex subunit 1 antibody; Tho1 antibody; THOC1 antibody

Rabbit IgG

This antibody was obtained by immunization of TH℃1 recombinant protein (Accession Number: NM_005131). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

THoc1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THoc1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THoc2, THoc3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THoc1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THoc1 in cancer cell lines results in promoted cancer cell apoptosis and reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THoc1 expression and therefore THoc1 may be a good target for cancer therapy. This antibody recognizes the 84kd THoc1 protein.

• Lin YS, Lin CH, Huang LD. The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent. Biochemical pharmacology. 86(2):242-52. 2013.
• Liu C, Yue B, Yuan C. Elevated expression of Thoc1 is associated with aggressive phenotype and poor prognosis in colorectal cancer. Biochemical and biophysical research communications. 468(1-2):53-8. 2015.