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Product Name
Tenascin-X antibody
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Description
Tenascin-X Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human breast cancer tissue, human heart tissue, human liver tissue, human lung tissue. Positive WB detected in mouse liver tissue, HT-1080 cells. Positive IP detected in mouse liver tissue. Observed molecular weight by Western-blot: 75 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Hexabrachion like protein antibody; HXBL antibody; Tenascin X antibody; tenascin XB antibody; TENX antibody; TN X antibody; TNX antibody; TNXB antibody; TNXB1 antibody; TNXB2 antibody; TNXBS antibody; XBS antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Tenascin-X recombinant protein (Accession Number: NM_032470). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115945(TNXB antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human kidney using Catalog No:115945(TNXB antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:115945(TNXB antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-TNXB (IP:Catalog No:115945, 4ug; Detection:Catalog No:115945 1:300) with mouse liver tissue lysate 4000ug.
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Background
Tenascin-X (TNXB) is a extracellular matrix glycoprotein predominantly located in the outer reticular lamina of the basement membrane (BM) (PMID: 23768946). It interacts with many other ECM proteins and it accelerates collagen fibrillogenesisin vitro. TNXB plays a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix. Deficiency of TNXB has been associated with the connective tissue disorder Ehlers-Danlos syndrome.
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References
- Gbadegesin RA, Brophy PD, Adeyemo A. TNXB mutations can cause vesicoureteral reflux. Journal of the American Society of Nephrology : JASN. 24(8):1313-22. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"