Tenascin-R antibody

Tenascin-R antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Tenascin-R Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, SH-SY5Y cells. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 180kd,160kd

ELISA, WB, IHC

Human; other species not tested.

Janusin antibody; Restrictin antibody; Tenascin R antibody; TN R antibody; TNR antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003285). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TNR, also named as Restrictin and Janusin, belongs to the tenascin family. Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides, TNR inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides, TNR results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1, TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B, TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. The antibody is specific to TNR.