TEM8 antibody

TEM8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TEM8 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, HeLa cells, mouse lung tissue, PC-13 cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 85 kDa,80 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

anthrax toxin receptor 1 antibody; ANTXR1 antibody; ATR antibody; FLJ10601 antibody; FLJ11298 antibody; FLJ21776 antibody; TEM8 antibody; Tumor endothelial marker 8 antibody

Rabbit IgG

This antibody was obtained by immunization of TEM8 recombinant protein (Accession Number: NM_018153). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Tumor endothelial marker 8 (TEM8, ANTXR1) and capillary morphogenesis protein 2 (CMG2, ANTXR2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding (PMID: 23271637). TEM8 is a highly-conserved single-pass cell-surface protein overexpressed on tumor-infiltrating vasculature, and is thought to play a positive role in endothelial cell activities related to angiogenesis (PMID: 11559528; 15777794 ). The long isoforms of TEM8 have been identified as an 80-85 kDa doublet, and experimental deglycosylation reduced the molecular mass to 70 kDa, indicating that TEM8 undergoes multiple glycosylations (PMID: 14871805; 15689409).