TDP1 antibody

TDP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TDP1 Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, HeLa cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 68 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

FLJ11090 antibody; TDP1 antibody; Tyr DNA phosphodiesterase 1 antibody

Rabbit IgG

This antibody was obtained by immunization of TDP1 recombinant protein (Accession Number: BC006083). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Tyrosyl DNA phosphodiesterase 1 (TDP1) is an enzyme capable of hydrolyzing phosphodiester bonds between tyrosine and the 3-phosphate of DNA, which are typically generated in a transient manner by DNA topoisomerase I (topo I) and it appears to be more mobile and diffusible than topo I, and it has a different distribution in the nucleus (PMID:15494395). TDP1 is involed in protecting cells against oxidative DNA damage, and with the impaired ability of TDP1-deficient cells to remove 3-phosphoglycolate (PMID:21041670). Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1)(PMID:17948061).

• Perego P, Cossa G, Tinelli S. Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition. Biochemical pharmacology. 83(1):27-36. 2012.