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TCN2 antibody

Cat.#: 115913

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Special Price 239.0 USD

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Product Information

  • Product Name
    TCN2 antibody
  • Documents
  • Description
    TCN2 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue. Positive WB detected in A375 cells, mouse small intestine tissue, rat liver tissue, Transfected HEK-293 cells. Observed molecular weight by Western-blot: 48kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    D22S676 antibody; D22S750 antibody; TC 2 antibody; TC II antibody; TC2 antibody; TCII antibody; TCN2 antibody; Transcobalamin 2 antibody; Transcobalamin II antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TCN2 recombinant protein (Accession Number: NM_001184726). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    A375 cells were subjected to SDS PAGE followed by western blot with Catalog No:115913(TCN2 antibody) at dilution of 1:100

    A375 cells were subjected to SDS PAGE followed by western blot with Catalog No:115913(TCN2 antibody) at dilution of 1:100

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115913(TCN2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115913(TCN2 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    TCN2 (Transcobalamin-2) is a vitamin B12 (cobalamin; Cbl) binding and transport protein in plasma that facilitates the cellular uptake of the vitamin. TCN2 is secreted in a constitutive fashion in most cells. Plasma TCN2 levels have been reported to be elevated in a number of diverse human diseases. Defects in TCN2 are cause of transcobalamin-2 deficiency. (10714245)
  • References
    • Sysel AM, Valli VE, Nagle RB, Bauer JA. Immunohistochemical quantification of the vitamin B12 transport protein (TCII), cell surface receptor (TCII-R) and Ki-67 in human tumor xenografts. Anticancer research. 33(10):4203-12. 2013.
    • Sysel AM, Valli VE, Bauer JA. Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues. Oncotarget. 6(4):2331-48. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"