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Product Name
TBXAS1 antibody
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Description
TBXAS1 Rabbit Polyclonal antibody. Positive WB detected in A549 cells, human colon tissue. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 60 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CYP5 antibody; CYP5A1 antibody; CytOChrome P450 5A1 antibody; GHOSAL antibody; TBXAS1 antibody; THAS antibody; Thromboxane A synthase antibody; TXA synthase antibody; TXAS antibody; TXS antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TBXAS1 recombinant protein (Accession Number: NM_001166254). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:115895(TBXAS1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115895(TBXAS1 antibody) at dilution of 1:50 (under 10x lens)
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Background
TBXAS1 catalyzes the conversion of the prostaglandin endoperoxide into thromboxane A2 as a potent vasoconstrictor and inducer of platelet aggregation.It was identified as novel airway fibroblast-specific markers with integrin-8 (ITGA8) (PMID:20435685). It was observed in the epithelium.It is a monomer with the molecular weight of 60 KDa. It also has two variants with 60.5 kDa and 52.3 kDa (PMID:1730669). It also reavels a molecular weight of 55 kDa in humen uterus (PMID:1386258).
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References
- Singh SR, Billington CK, Sayers I, Hall IP. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? American journal of physiology. Lung cellular and molecular physiology. 299(2):L169-83. 2010.
- Mousa AA, Strauss JF, Walsh SW. Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia. Hypertension. 59(6):1249-55. 2012.
- Singh SR, Billington CK, Sayers I, Hall IP. Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity. Respiratory research. 15:57. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"