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Product Name
TAX1BP1 antibody
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Description
TAX1BP1 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, HepG2 cells, mouse kidney tissue, mouse liver tissue, mouse lung tissue, mouse testis tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 68 kDa, 85 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CALCOCO3 antibody; T6BP antibody; Tax1 binding protein 1 antibody; TAX1BP1 antibody; TRAF6 binding protein antibody; TXBP151 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TAX1BP1 recombinant protein (Accession Number: NM_006024). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115858(TAX1BP1 antibody) at dilution of 1:500
Immunofluorescent analysis of HepG2 cells using Catalog No:115858(TAX1BP1 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5. TAX1BP1 has 4 isoforms with MW 65-68 kDa and 86-91 kDa. Western blot analysis showed that TAX1BP1 is expressed as an 86 kDa or a 68 kDa protein.
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