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Product Name
SYNCRIP antibody
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Description
SYNCRIP Rabbit Polyclonal antibody. Positive WB detected in A431 cells, HEK-293 cells, Jurkat cells. Positive IP detected in A431 cells. Observed molecular weight by Western-blot: 62-74 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
dJ3J17.2 antibody; GRY RBP antibody; hnRNP Q antibody; HNRPQ antibody; HNRPQ1 antibody; NS1 assOCiated protein 1 antibody; NSAP1 antibody; pp68 antibody; RP1 3J17.2 antibody; SYNCRIP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SYNCRIP recombinant protein (Accession Number: NM_001159674). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:115780(SYNCRIP antibody) at dilution of 1:500
IP Result of anti-SYNCRIP (IP:Catalog No:115780, 4ug; Detection:Catalog No:115780 1:500) with A431 cells lysate 1200ug.
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Background
Synaptotagmin-binding, cytoplasmic RNA-interacting protein(SYNCRIP), also identified as hnRNP Q, involves in mRNA processing mechanisms. It's component of the CRD-mediated complex that promotes MYC mRNA stability. Also it is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences.
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