SUMO2/3 antibody

SUMO2/3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SUMO2/3 Rabbit Polyclonal antibody. Positive WB detected in Apoptosised HeLa cells, Recombinant protein. Positive IHC detected in human gliomas tissue. Positive IF detected in HEK-293 cells. Observed molecular weight by Western-blot: 11-14kd

ELISA, WB, IHC, IF

Human; other species not tested.

HSMT3 antibody; Sentrin 2 antibody; SMT3 homolog 2 antibody; SMT3B antibody; SMT3H2 antibody; SUMO 2 antibody; SUMO 3 antibody; SUMO2 antibody; SUMO3 antibody; Ubiquitin like protein SMT3B antibody

Rabbit IgG

This antibody was obtained by immunization of SUMO2/3 recombinant protein (Accession Number: NM_006937). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Ubiquitin is most famous for its function in targeting proteins for degradation by the 26S proteasome, ubiquitin needs to be attached to a substrate in chains (polyubiquitylation) before being recognized by proteasome. Similarly, SUMO (small ubiquitin-related modifier) can be linked to substrates in chains (polysumoylation), SUMO modification has been implicated in many important cellular processes including the control of genome stability, signal transduction, targeting to and formation of nuclear compartments, cell cycle and meiosis. There are 4 confirmed SUMO isoforms in human, SUMO-1, SUMO-2, SUMO-3 and SUMO-4. SUMO-2 and SUMO-3 are nearly identical but are distinct from SUMO-1. SUMO2/3 conjugation was recently widely involved in neuroprotective activities. A substitution (M55V) of SUMO4 was strongly associated with the pathogenesis of type 1 diabetes (T1D) involving NF kappa B related mechanisms.