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Product Name
Stanniocalcin 2 antibody
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Description
Stanniocalcin 2 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Positive IHC detected in human breast cancer tissue, human kidney tissue, human renal cell carcinoma tissue, human stomach cancer tissue. Observed molecular weight by Western-blot: 33 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
stanniOCalcin 2 antibody; StanniOCalcin related protein antibody; STC 2 antibody; STC related protein antibody; STC2 antibody; STCRP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Stanni℃alcin 2 recombinant protein (Accession Number: NM_003714). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115675(STC2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115675(STC2 antibody) at dilution of 1:100 (under 10x lens)
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Background
Stanniocalcin (STC) is a family of secreted glycoprotein hormones that originally discovered in the corpuscles of Stannius, an endocrine gland of fish. STC1 and STC2, two homologues of STC family, are reported to involve in calcium and phosphate homeostasis. It is expressed in a wide variety of tissues such as kidney, spleen, heart, and pancreas. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. STC2 overexpression could promote tumor cell proliferation, invasion and metastasis in prostate cancer, ovarian cancer or neuroblastoma. STC2 is also vital for cytoprotective properties when exposed to ER stress and hypoxia.
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References
- Meyer HA, Tölle A, Jung M. Identification of stanniocalcin 2 as prognostic marker in renal cell carcinoma. European urology. 55(3):669-78. 2009.
- Kashyap MK, Pawar HA, Keerthikumar S. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. Cancer biomarkers : section A of Disease markers. 12(1):1-9. 2013.
- Arigami T, Uenosono Y, Ishigami S. Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer. Oncology reports. 30(6):2838-44. 2013.
- Parris TZ, Kovács A, Aziz L. Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma. International journal of cancer. 134(7):1617-29. 2014.
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