SRRM1 antibody

SRRM1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SRRM1 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in mouse liver tissue, HeLa cells, Jurkat cells, UV treated HEK-293 cells. Observed molecular weight by Western-blot: 120-160 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

160 KD antibody; POP101 antibody; SRM160 antibody; SRRM1 antibody

Rabbit IgG

This antibody was obtained by immunization of SRRM1 recombinant protein (Accession Number: NM_005839). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SRRM1, also named as SRM160 and POP101, contains one PWI domain and belongs to the splicing factor SR family. As part of pre- and post-splicing multiprotein mRNP complexes, SRRM1 is involved in numerous pre-mRNA processing events. It promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. SRRM1 stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. It binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. SRRM1 binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. SRRM1, a protein of high molecular weight(120-160kd), has a heavy glycosylation level and is normally highly phosphorylated. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SRRM1.

• Wojcechowskyj JA, Didigu CA, Lee JY. Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry. Cell host & microbe. 13(5):613-23. 2013.