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Product Name
SRPX2 antibody
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Description
SRPX2 Rabbit Polyclonal antibody. Positive IHC detected in human placenta tissue, human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human skin tissue, human spleen tissue. Positive WB detected in human placenta tissue, HepG2 cells, human brain tissue, human kidney tissue, Transfected HEK-293 cells. Observed molecular weight by Western-blot: 53kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
BPP antibody; CBPS antibody; PMGX antibody; RESDX antibody; SRPUL antibody; SRPX2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SRPX2 recombinant protein (Accession Number: NM_014467). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:115599(SRPX2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human placenta using Catalog No:115599(SRPX2 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human placenta using Catalog No:115599(SRPX2 antibody) at dilution of 1:100 (under 40x lens)
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115599(SRPX2 Antibody) at dilution of 1:1000
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Background
SRPX2 (sushi-repeat-containing protein, X-linked 2) is a secreted protein expressed in neurons of the human adult brain, including the rolandic area (PMID: 20874700). Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level, SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR, the urokinase-type plasminogen activator (uPA) receptor (PMID: 18718938). It is involved in seizure disorders, angiogenesis and cellular adhesion (PMID: 22242148; 19667118; 16497722). The involvement of SRPX2 in disorders of language cortex and cognition suggests it has an important role in the perisylvian region critical for language and cognitive development (PMID: 16497722).
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References
- Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Bradfield PF, Szepetowski P, Imhof BA. Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(12):4105-16. 2009.
- Royer-Zemmour B, Ponsole-Lenfant M, Gara H. Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. Human molecular genetics. 17(23):3617-30. 2008.
- Gao Z, Zhang J, Bi M. SRPX2 promotes cell migration and invasion via FAK dependent pathway in pancreatic cancer. International journal of clinical and experimental pathology. 8(5):4791-8. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"