SPRED2 antibody

SPRED2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SPRED2 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue. Positive WB detected in mouse testis tissue, mouse brain tissue, rat brain tissue. Observed molecular weight by Western-blot: 46-48 kDa

ELISA, WB, IHC

Human, Mouse, Rat; other species not tested.

FLJ21897 antibody; FLJ31917 antibody; Spred 2 antibody; SPRED2 antibody

Rabbit IgG

This antibody was obtained by immunization of SPRED2 recombinant protein (Accession Number: NM_181784). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SPRED2 is a member of the SPRED family of proteins that modulate growth factor receptor signaling by inhibiting the Ras-MAPK cascade (PMID: 17094949). SPRED family members are characterized by an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a C-terminal Sprouty-related domain (SPR) (PMID: 17691106). Three mammalian SPREDs (SPRED1-3) have been described. In adult tissues, SPRED2 is expressed ubiquitously, but most highly expressed in glandular epithelia (PMID: 15580519; 17691106). Reduced expression level of SPRED2 has been reported in human hepatocellular carcinoma (HCC), suggesting SPRED2 may play a role in tumorgenesis (PMID: 16652141). Gene disruption of SPRED2 causes dwarfism (PMID: 15946934).