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Product Name
SOS1 antibody
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Description
SOS1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, K-562 cells. Observed molecular weight by Western-blot: 150 kDa
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Tested applications
ELISA, WB, IF, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GF1 antibody; GGF1 antibody; GINGF antibody; HGF antibody; NS4 antibody; Son of sevenless homolog 1 antibody; SOS 1 antibody; SOS1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_005633). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IF: 1:10-1:100
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115508(SOS1 antibody) at dilution of 1:500
IP Result of anti-SOS1 (IP:Catalog No:115508, 4ug; Detection:Catalog No:115508 1:500) with mouse brain tissue lysate 4000ug.
Immunofluorescent analysis of HeLa cells using Catalog No:115508(SOS1 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
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Background
SOS1 promotes the exchange of Ras-bound GDP by GTP. EPS8, E3B1 and SOS1 form a tricomplex in vivo that exhibits RAC-specific guanine nucleotide exchange factor activity in vitro. Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1). Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4). The antibody is specific to SOS1.
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