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Product Name
Sorbitol dehydrogenase antibody
- Documents
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Description
Sorbitol dehydrogenase Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in HeLa cells, human kidney tissue, rat liver tissue. Observed molecular weight by Western-blot: 38 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
L iditol 2 dehydrogenase antibody; SDH antibody; Sorbitol dehydrogenase antibody; SORD antibody; SORD1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Sorbitol dehydrogenase recombinant protein (Accession Number: NM_003104). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:115500(SORD antibody) at dilution of 1:500
IP Result of anti-SORD (IP:Catalog No:115500, 4ug; Detection:Catalog No:115500 1:1000) with mouse liver tissue lysate 4000ug.
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Background
SORD(Sorbitol dehydrogenase) is also named as L-iditol 2-dehydrogenase and belongs to the zinc-containing alcohol dehydrogenase family. It catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase, makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. This protein can form a homotetramer(PMID:12962626). Measurement of SORD is a specific indicator of liver cell damage and parenchymal.
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References
- Lanaspa MA, Ishimoto T, Li N. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nature communications. 4:2434. 2013.
- Dai J, Xu W, Zhao X. Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa. Reproduction (Cambridge, England). 151(3):227-37. 2016.
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