Human SCN2B (Fc Tag) recombinant protein

Human SCN2B (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SCN2B plays a key role in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. Alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.They are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. SCN2B causes an increase in the plasma membrane surface area and in its folding into microvilli. SCN2B also interacts with TNR and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier.

Sodium channel subunit beta-2

VOLTAGE-GATED; ATFB14; NEURONAL VOLTAGE-GATED SODIUM CHANNEL BETA 2 SUBUNIT; SODIUM CHANNEL; GM183; SODIUM CHANNEL BETA 2 SUBUNIT; BETA POLYPEPTIDE; UNQ326/PRO386; AI840361; TYPE II; 2810451E09RIK; SODIUM CHANNEL SUBUNIT BETA-2

O60939

SCN2B; UNQ326/PRO386

Human Cells

A DNA sequence encoding the human SCN2B (O60939) (Met1-Ala159) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human SCN2B /Fc is a disulfide-linked homodimer. The reduced monomer comprises 371 amino acids and has a predicted molecular mass of 42.2 kDa. The apparent molecular mass of the protein is approximately 53-57 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE