SMN-Exon7 antibody

SMN-Exon7 antibody

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• Material Safety Data Sheets (MSDS)

SMN-Exon7 Mouse Monoclonal antibody. Positive WB detected in HEK-293 cells, HeLa cells, HepG2 cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 40 kDa

ELISA, WB, IF

Human,Mouse; other species not tested.

Component of gems 1 antibody; Gemin 1 antibody; SMN antibody; SMN1 antibody; SMN2 antibody; SMNC antibody; SMNT antibody; Survival motor neuron protein antibody; T BCD541 antibody

Mouse IgG1

This antibody was obtained by immunization of SMN-Exon7 recombinant protein (Accession Number: NM_000344). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of anterior horn cells in the spinal cord and concomitant symmetrical muscle weakness and atrophy (PMID: 16364894 ). SMA is caused by deletion or mutations of the survival motor neuron (SMN1) gene. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional (PMID: 17355180). A large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein (PMID: 10369862). The level of SMN protein correlates with phenotypic severity of SMA. This antibody, 60255-1-Ig, raised against the C-ternimal region (275-294aa) encoded by the exon 7.