SMARCE1 antibody

SMARCE1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SMARCE1 Mouse Monoclonal antibody. Positive IHC detected in human breast cancer tissue. Positive IF detected in HEK-293 cells. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 55 kDa

ELISA, WB, IHC, IF

Human; other species not tested.

BAF57 antibody; BRG1 assOCiated factor 57 antibody; SMARCE1 antibody

Mouse IgG1

This antibody was obtained by immunization of SMARCE1 recombinant protein (Accession Number: NM_003079). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Via antagonizing chromatin-mediated transcriptional repression, the SWI/SNF complex in S. cerevisiae and Drosophila is thought to facilitate transcriptional activation of specific genes. The BRG1/brm-associated factors, or SMARCE1, complex in mammals is functionally related to SWI/SNF and consists of 9 to 12 subunits, some of which are homologous to SWI/SNF subunits. It contains a DNA-binding HMG domain and performs multiple biological functions, including DNA-, protein- and chromatin-binding, transcription coactivating activity, chromatin modification, DNA-dependent negative regulation of transcription, regulation of transcription of the RNA polymerase II promoter. In addition, SMARCE1, as an ER (estrogen receptor) subtype-selective modulator, regulates ER mediated transcription in a ligand-dependent manner and also directly binds to AR (androgen receptor) to alter its activity