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Product Name
SLC45A2 antibody
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Description
SLC45A2 Rabbit Polyclonal antibody. Positive IP detected in HL-60 cells. Positive WB detected in HL-60 cells, MCF7 cells. Observed molecular weight by Western-blot: 50-55 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
1A1 antibody; AIM1 antibody; MATP antibody; Melanoma antigen AIM1 antibody; Protein AIM 1 antibody; SHEP5 antibody; SLC45A2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SLC45A2 recombinant protein (Accession Number: NM_001297417). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
HL-60 cells were subjected to SDS PAGE followed by western blot with Catalog No:115379(SLC45A2 antibody) at dilution of 1:1000
IP Result of anti-SLC45A2 (IP:Catalog No:115379, 4ug; Detection:Catalog No:115379 1:500) with HL-60 cells lysate 1600ug.
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Background
SLC45A2, also named as AIM1 and MATP, belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. It is a melanocyte differentiation antigen. SLC45A2 may transport substances required for melanin biosynthesis. (PMID:17768386,21677667)Mutation of SLC45A2 cause oculocutaneous albinism type 4 (ocA4) which is disorder of pigmentation characterized by reduced biosynthesis of melanin in the skin, hair and eyes.
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References
- Cullinane AR, Vilboux T, O'Brien K. Homozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropenia. The Journal of investigative dermatology. 131(10):2017-25. 2011.
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