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SIRP BETA 1 antibody

Cat.#: 115239

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Special Price 239.0 USD

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Product Information

  • Product Name
    SIRP BETA 1 antibody
  • Documents
  • Description
    SIRP BETA 1 Rabbit Polyclonal antibody. Positive WB detected in U-937 cells, A375 cells, PC-3 cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 43 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CD172b antibody; DKFZp686A05192 antibody; FLJ26614 antibody; SIRP BETA 1 antibody; SIRPB1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SIRP BETA 1 recombinant protein (Accession Number: NM_001083910). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115239(SIRPB1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115239(SIRPB1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115239(SIRPB1 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115239(SIRPB1 antibody) at dilution of 1:50 (under 40x lens)

    U-937 cells were subjected to SDS PAGE followed by western blot with Catalog No:115239(SIRPB1 Antibody) at dilution of 1:1000

    U-937 cells were subjected to SDS PAGE followed by western blot with Catalog No:115239(SIRPB1 Antibody) at dilution of 1:1000

  • Background
    SIRPB1 is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are cell surface signaling receptors differentially expressed in leukocytes and the central nervous system. SIRPB1 interacts with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. It also participates in the recruitment of tyrosine kinase SYK.
  • References
    • Satoh J, Tabunoki H, Ishida T. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. 31(4):363-75. 2011.
    • Visani G, Sapienza MR, Isidori A. SNPs array karyotyping reveals a novel recurrent 20p13 amplification in primary myelofibrosis. PloS one. 6(11):e27560. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"