SH2D1A antibody

Cat.#: 115178

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Product Information

  • Product Name
    SH2D1A antibody
  • Documents
  • Description
    SH2D1A Rabbit Polyclonal antibody. Positive WB detected in mouse thymus tissue. Observed molecular weight by Western-blot: 16kd
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    DSHP antibody; Duncan disease SH2 protein antibody; EBVS antibody; FLJ18687 antibody; FLJ92177 antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; SH2 domain protein 1A antibody; SH2D1A antibody; SLAM assOCiated protein antibody; XLP antibody; XLPD antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SH2D1A recombinant protein (Accession Number: NM_002351). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:115178(SH2D1A antibody) at dilution of 1:500

    mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:115178(SH2D1A antibody) at dilution of 1:500

  • Background
    SH2D1A, also named as DSHP and SAP, is an inhibitor of the SLAM self-association. It acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. SH2D1A mediates interaction between FYN and SLAMF1. Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1).
  • References
    • Ding S, Liang Y, Zhao M. Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis and rheumatism. 64(9):2953-63. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"