SGSH antibody

Cat.#: 115173

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Product Information

  • Product Name
    SGSH antibody
  • Documents
  • Description
    SGSH Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, Transfected HEK-293 cells. Positive IHC detected in human pancreas cancer tissue, human liver cancer tissue.
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    HSS antibody; MPS3A antibody; SFMD antibody; SGSH antibody; Sulfoglucosamine sulfamidase antibody; Sulphamidase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SGSH recombinant protein (Accession Number: NM_000199). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115173(SGSH Antibody) at dilution of 1:600

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115173(SGSH Antibody) at dilution of 1:600

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:115173(SGSH Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:115173(SGSH Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:115173(SGSH Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:115173(SGSH Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    SGSH(N-sulphoglucosamine sulphohydrolase) is also named as HSS, sulphamidase and belongs to the sulfatase family. Sulfamidase is synthesized as a 62 kDa precursor protein, which is modified with mannose 6-phosphate (M6P) residues, allowing their recognition by mannose-6-phosphate receptors in the Golgi complex and ensuring transport to the endosomal/lysosomal system(PMID:21671382). It catalyzes the third step of degradation of glucosaminoglycans and is required for the degradation of heparan sulphate. Defects in SGSH are the cause of mucopolysaccharidosis type 3A (MPS3A), also known as Sanfilippo syndrome A.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"