Product Name

SETD2 antibody

Documents

Description

SETD2 Rabbit Polyclonal antibody. Positive WB detected in transfected cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 250 kDa

Tested applications

ELISA, WB, IF

Species reactivity

Human; other species not tested.

Alternative names

FLJ16420 antibody; FLJ22472 antibody; FLJ23184 antibody; FLJ45883 antibody; FLJ46217 antibody; HIF 1 antibody; HIF1 antibody; HIP 1 antibody; hSET2 antibody; HSPC069 antibody; Huntingtin yeast partner B antibody; HYPB antibody; KIAA1732 antibody; KMT3A antibody; Lysine N methyltransferase 3A antibody; p231HBP antibody; SET domain containing 2 antibody; SET2 antibody; SETD2 antibody

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of Peptide (Accession Number: NM_014159). Purification method: Antigen affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

WB: N/AIF: 1:20-1:200

Validations

WB result of SETD2 antibody (Catalog No:115222, 1:500) with siRNA transfected U2-OS cells.

Immunofluorescent analysis of HepG2 cells using Catalog No:115222(SETD2 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG

Background

SETD2, also named as HIF1, HYPB, KIAA1732, KMT3A, SET2, p231HBP, hSET2 and HIP-1, belongs to the histone-lysine methyltransferase family and SET2 subfamily. It is a histone methyltransferase that methylates 'Lys-36' of histone H3. SETD2 probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. It binds DNA at promoters. SETD2 may also act as a transcription activator that binds to promoters.(PMID:16118227) It is a potential tumour suppressor gene in breast cancer.(PMID:20944102) This antibody is specific to SETD2.

SETD2 antibody

Product Information

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