SAFB antibody

SAFB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SAFB Rabbit Polyclonal antibody. Positive IF detected in A431 cells. Positive IHC detected in human breast cancer tissue, human testis tissue. Positive WB detected in MCF-7 cells, A431 cells, HEK-293 cells, HeLa cells, HepG2 cells, MCF7 cells. Observed molecular weight by Western-blot: 150 kDa

ELISA, WB, IF, IHC

Human; other species not tested.

DKFZp779C1727 antibody; HAP antibody; HET antibody; HSP27 ERE TATA binding protein antibody; SAF B antibody; SAF B1 antibody; SAFB antibody; SAFB1 antibody; scaffold attachment factor B antibody; Scaffold attachment factor B1 antibody

Rabbit IgG

This antibody was obtained by immunization of SAFB recombinant protein (Accession Number: NM_001201338). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport. hnRNPs also bind heterogeneous nuclear RNA (hnRNA), the transcripts produced by RNA polymerase II. SAFB (scaffold attachment factor B) is a nuclear matrix-associated protein that binds to matrix- or scaffold-associating regions (MARs or SARs) on DNA and interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors (SR proteins). SAFB, also designated HAP (hnRNP A1 associated protein) and HET (HSP 27-ERE-TATA-binding protein) is a proven hnRNP protein that has a speckled distribution in the nucleus and, in response to stress agents such as heat shock, is recruited to a few, large nuclear granules, called perichromatin granules. SAFB also binds to the estrogen receptor (ER) and is expressed in several breast cancer cell lines at varying levels. Subsequently, SAFB may play a role in breast cancer by mediating cellular proliferation and division. This antibody specifically reacts whith the isoform 1 of human SAFB protein.