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S1PR2 antibody

Cat.#: 114969

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Product Information

  • Product Name
    S1PR2 antibody
  • Documents
  • Description
    S1PR2 Rabbit Polyclonal antibody. Positive IP detected in MCF-7 cells. Positive WB detected in MCF7 cells, HeLa cells. Observed molecular weight by Western-blot: 40-50 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    AGR16 antibody; EDG 5 antibody; EDG5 antibody; Gpcr13 antibody; H218 antibody; LPB2 antibody; S1P receptor 2 antibody; S1P receptor Edg 5 antibody; S1P2 antibody; S1PR2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of S1PR2 recombinant protein (Accession Number: NM_004230). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:1000

  • Validations

    MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:114969(S1PR2 antibody) at dilution of 1:100

    MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:114969(S1PR2 antibody) at dilution of 1:100

    IP Result of anti-S1PR2 (IP:Catalog No:114969, 4ug; Detection:Catalog No:114969 1:300) with MCF-7 cells lysate 1320ug.

    IP Result of anti-S1PR2 (IP:Catalog No:114969, 4ug; Detection:Catalog No:114969 1:300) with MCF-7 cells lysate 1320ug.

  • Background
    S1PR2 (sphingosine-1-phosphate receptor 2), also known as as S1P2 or EDG5, is one of five G-protein-coupled receptors for sphingosine-1-phosphate (S1P), a biologically active metabolite of sphingolipid (PMID: 18787560). S1P1 and its receptors have important regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems (PMID: 21339489). S1PR2 plays a role in acute vascular inflammation (PMID: 23723450). S1PR2 signaling is implicated in STAT3 activation (PMID: 22606352).
  • References
    • Pan HY, Yang H, Shao MY. Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. International endodontic journal. 48(5):460-8. 2015.
    • Kim GS, Yang L, Zhang G. Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke. Nature communications. 6:7893. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"