RTN1 (Isoform RTN1-C) antibody

Cat.#: 114861

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Product Information

  • Product Name
    RTN1 (Isoform RTN1-C) antibody
  • Documents
  • Description
    RTN1 (Isoform RTN1-C) Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human brain tissue. Positive IHC detected in human brain tissue, human placenta tissue. Observed molecular weight by Western-blot: 23 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    NSP antibody; NSP-C antibody; reticulon 1 antibody; RTN1 antibody; RTN1-C antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RTN1 (Isoform RTN1-C) recombinant protein (Accession Number: NM_206852). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114861(RTN1 antibody) at dilution of 1:800

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114861(RTN1 antibody) at dilution of 1:800

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114861(RTN1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114861(RTN1 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    Reticulon (RTN) proteins are a group of membrane-bound proteins that largely reside in endoplasmic reticulum (ER) (PMID: 18177508). Reticulon proteins share a common sequence feature, the reticulon homology domain (RHD). They are involved in shaping the tubular endoplasmic reticulum network, membrane trafficking, inhibition of axonal growth, and apoptosis (PMID: 24218324). Four mammalian reticulons (RTN1-4) exist. Human RTN1 (also known as NSP) gene is expressed predominantly in neuroendocrine tissues, and produces three isoforms termed RTN1-A (NSP-A), RTN1-B (NSP-B), and RTN1-C (NSP-C). This antibody is raised against the full-length protein of human RTN1-C.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"