RSPO3 antibody

RSPO3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RSPO3 Mouse Monoclonal antibody. Positive WB detected in human skeletal muscle tissue, A549 cells. Observed molecular weight by Western-blot: 32 kDa

ELISA, WB

Human; other species not tested.

CRISTIN1 antibody; FLJ14440 antibody; hPWTSR antibody; hRspo3 antibody; Protein with TSP type 1 repeat antibody; PWTSR antibody; R spondin 3 antibody; Roof plate specific spondin 3 antibody; RSPO3 antibody; THSD2 antibody

Mouse IgG2b

This antibody was obtained by immunization of RSPO3 recombinant protein (Accession Number: NM_032784). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RSPO3, also named as R-spondin-3, is a 272 amino acid protein, which contains 1 TSP type-1 domain and 2 FU (furin-like) repeats. RSPO3 may be a secreted protein and belongs to the R-spondin family. RSPO3 is expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. The four R-spondins (RSPO1–4) and three related leucinerich repeat-containing G-protein coupled receptors, LGR4, LGR5, and LGR6 (LGR4–6), constitute a ligand–receptor system that plays critical roles in development, stem cell survival, and oncogenesis. Ectopic expression of RSPO2/3in mouse mammary epithelial cells led to an increase in invasiveness in vitro and in tumor formation and metastasis in vivo.