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Product Name
RON, MST1R antibody
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Description
RON, MST1R Rabbit Polyclonal antibody. Positive WB detected in mouse lung tissue. Observed molecular weight by Western-blot: 140 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CD136 antibody; CDw136 antibody; MSP receptor antibody; MST1R antibody; p185 Ron antibody; Protein tyrosine kinase 8 antibody; PTK8 antibody; RON antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RON, MST1R recombinant protein (Accession Number: BQ936677 NM_002447). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:114785(RON, MST1R antibody) at dilution of 1:300
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Background
RON (also referred to as MST1R, or CD136) is a receptor tyrosine kinase that belongs to the MET proto-oncogene family. The precursor RON is produced as a glycosylated, single chain that is cleaved into a 185-kDa heterodimer of α (35 kDa) and β (150 kDa) subunits connected by a disulfide bond (PMID: 8062829). It is activated upon binding to its ligand, macrophage-stimulating protein (MSP, also known as MST1 and HGFL). RON signalling is essential for embryonic development and regulates many physiological processes including cell survival, migration and differentiation.
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