ROCK1-Specific antibody

ROCK1-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ROCK1-Specific Rabbit Polyclonal antibody. Positive IHC detected in human spleen tissue, human renal cell carcinoma tissue. Positive WB detected in HeLa cells, HT-1080 cells, mouse spleen tissue, NIH/3T3 cells. Observed molecular weight by Western-blot: 150-160kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

p160 ROCK 1 antibody; P160ROCK antibody; PRO0435 antibody; ROCK1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_005406). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RocK1, also named as p160RocK and NY-REN-35, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. RocK1 phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. RocK1 is required for centromere positioning and centromere-dependent exit from mitosis. It is necessary for apoptotic membrane blebbing. RocK1 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. The antibody is specific to RocK1.

• Pedraza CE, Taylor C, Pereira A. Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase. ASN neuro. 6(4):. 2014.