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Product Name
RNASEH2C antibody
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Description
RNASEH2C Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue, human lung tissue, human skin tissue, human spleen tissue. Positive WB detected in human testis tissue, HEK-293 cells, HeLa cells, human spleen tissue. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 22 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human; other species not tested.
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Alternative names
AGS3 antibody; AYP1 antibody; FLJ20974 antibody; Ribonuclease H2 subunit C antibody; ribonuclease H2 antibody; subunit C antibody; Ribonuclease HI subunit C antibody; RNase H1 small subunit antibody; RNase H2 subunit C antibody; RNASEH2C antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RNASEH2C recombinant protein (Accession Number: NM_032193). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:114731(RNASEH2C antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human brain using Catalog No:114731(RNASEH2C antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:114731(RNASEH2C antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-RNASEH2C (IP:Catalog No:114731, 3ug; Detection:Catalog No:114731 1:500) with HEK-293 cells lysate 3200ug.
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Background
RNASEH2C represents ribonuclease H2, subunit C
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References
- Pizzi S, Sertic S, Orcesi S. Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability. Human molecular genetics. 24(3):649-58. 2015.
- Lindsey-Boltz LA, Kemp MG, Hu J, Sancar A. Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair. The Journal of biological chemistry. 290(50):29801-7. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"