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Product Name
Human RSK3/RPS6KA2 (GST Tag) recombinant protein
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Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
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Protein name
Ribosomal protein S6 kinase alpha-2
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Protein short names
S6K-alpha-2; p90-RSK 2; p90RSK2; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; RSK-3
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Uniprot ID
Q15349
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Gene Name
RPS6KA2; MAPKAPK1C; RSK3
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human RPS6KA2 isoform 1 (Q15349-1) (Met 1-Leu 733) was fused with the GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RPS6KA2/GST chimera consists of 957 amino acids and migrates as an approximatly 110 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 84 % as determined by SDS-PAGE
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Activity
The specific activity was determined to be 41 nmol/min/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate.
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Validations
Human RSK3 / RPS6KA2 Protein (GST Tag) SDS-PAGE
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