-
Product Name
RERG antibody
- Documents
-
Description
RERG Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue, human liver cancer tissue, human placenta tissue, human skin tissue. Positive WB detected in MCF7 cells, NIH/3T3 cells. Observed molecular weight by Western-blot: 23-26 kDa
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human, Mouse; other species not tested.
-
Alternative names
RERC antibody; RERG antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of RERG recombinant protein (Accession Number: NM_032918). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
-
Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:114692(RERG antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:114692(RERG antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:114692(RERG antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:114692(RERG Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:114692(RERG Antibody) at dilution of 1:50 (under 40x lens)
-
Background
RERG (Ras-related and estrogen-regulated growth inhibitor), a gene that encodes a small GTP binding and hydrolyzing protein (GTPase) of the Ras superfamily, is a novel gene that was first reported in breast cancer. RERG gene expression is stimulated by the estrogen receptor alpha (ERalpha), and RERG gene expression is absent in ER-negative breast cancer. RERG can bind and hydrolyze GTP as a GTP/GDP molecular switch, and RERG has been shown to possess growth inhibitory activity in breast cancer cells.
-
References
- Habashy HO, Powe DG, Glaab E. RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype. Breast cancer research and treatment. 128(2):315-26. 2011.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"