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Product Name
Recoverin antibody
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Description
Recoverin Rabbit Polyclonal antibody. Positive WB detected in mouse eye tissue, Y79 cells. Observed molecular weight by Western-blot: 23kd
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
RCVRN antibody; Protein CAR antibody; recoverin antibody; RCV1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Recoverin recombinant protein (Accession Number: NM_002903). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse eye tissue were subjected to SDS PAGE followed by western blot with Catalog No:114675(RCVRN antibody) at dilution of 1:400
Immunofluorescent analysis of MCF-7 cells, using RCVRN antibody Catalog No:114675 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
Recoverin, belonging to a family of the neuronal calcium sensor (NCS) proteins, has a restricted expression in retinal photoreceptors or neurons or neuroendocrine cells. It has been suggested to play a role in light and dark adaptation by regulating rhodopsin phosphorylation. Recently, it has been found that autoantibodies against recoverin (24 kDa) have been strongly associated with cancer -associated retinopathy (CAR) syndrome, a paraneoplastic disease of the retina. But functions of recoverin in cancer cells remain unknown.
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References
- Kicic A, Shen WY, Wilson AS, Constable IJ, Robertson T, Rakoczy PE. Differentiation of marrow stromal cells into photoreceptors in the rat eye. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(21):7742-9. 2003.
- Keller RL, Kania SA, Hendrix DV, Ward DA, Abrams K. Evaluation of canine serum for the presence of antiretinal autoantibodies in sudden acquired retinal degeneration syndrome. Veterinary ophthalmology. 9(3):195-200. 2006.
- Huo SJ, Li YC, Xie J. Transplanted olfactory ensheathing cells reduce retinal degeneration in Royal College of Surgeons rats. Current eye research. 37(8):749-58. 2012.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"