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Product Name
RDH11 antibody
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Description
RDH11 Rabbit Polyclonal antibody. Positive IF detected in PC-3 cells. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 35 kDa
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Tested applications
ELISA, IF, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ARSDR1 antibody; CGI 82 antibody; FLJ32633 antibody; HCBP12 antibody; MDT1 antibody; PSDR1 antibody; RALR1 antibody; RDH11 antibody; Retinal reductase 1 antibody; Retinol dehydrogenase 11 antibody; SCALD antibody; SDR7C1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RDH11 recombinant protein (Accession Number: NM_016026). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:50-1:500
IF: 1:10-1:100
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Validations
Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using Catalog No:114584(RDH11 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunofluorescent analysis of PC-3 cells using Catalog No:114584(RDH11 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
RDH11(Retinol dehydrogenase 11) is also named as ARSDR1(androgen-regulated short-chain dehydrogenase/reductase 1 ), PSDR1(prostate short-chain dehydrogenase/reductase 1) and belongs to the short-chain dehydrogenases/reductases (SDR) family. RDH11 is involved in steroid synthesis and/or degradation in normal and neoplastic prostate epithelium, and, as such, it may be a key enzyme involved in maintaining intracellular balance of steroid hormones in these cells(PMID:11245473). The deduced protein contains 318 amino acids, and the transcript contains 2 potential polyadenylation signals. It has 2 isoforms produced by alternative splicing.
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