RBM24 antibody

Cat.#: 114606

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Product Information

  • Product Name
    RBM24 antibody
  • Documents
  • Description
    RBM24 Rabbit Polyclonal antibody. Positive IHC detected in human skeletal muscle tissue. Positive WB detected in HeLa cells.
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    dJ259A10.1 antibody; FLJ26355 antibody; FLJ30829 antibody; FLJ37697 antibody; RBM24 antibody; RNA binding motif protein 24 antibody; RNA binding protein 24 antibody; RNPC6 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RBM24 recombinant protein (Accession Number: NM_153020). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114606(RBM24 Antibody) at dilution of 1:600

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114606(RBM24 Antibody) at dilution of 1:600

    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:114606(RBM24 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:114606(RBM24 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:114606(RBM24 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:114606(RBM24 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    RNA-binding proteins have a pivotal role in post-transcriptionally regulating gene expression. During early development they exhibit temporally and spatially regulated expression pattern, and affect the proteome of a single cell by controlling alternative splicing, transport, localization, and stability of their target RNAs [PMID:22510371]. Their expression are tissue-specific, and their crucial influence on the protein set-up especially in muscle cells has become recognized recently [PMID:21982546]. RBM24 is one RNA-binding protein and plays a fundamental role in regulating cardiac gene expression, sarcomeric assembly, and cardiac contractility and may thus represent a novel pathway to cardiomyopathy [PMID:20338237].
  • References
    • Grifone R, Xie X, Bourgeois A, Saquet A, Duprez D, Shi DL. The RNA-binding protein Rbm24 is transiently expressed in myoblasts and is required for myogenic differentiation during vertebrate development. Mechanisms of development. 134:1-15. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"