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Product Name
PUM2 antibody
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Description
PUM2 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue. Observed molecular weight by Western-blot: 140 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FLJ36528 antibody; KIAA0235 antibody; PUM2 antibody; PUMH2 antibody; Pumilio 2 antibody; Pumilio homolog 2 antibody; pumilio homolog 2 (Drosophila) antibody; PUML2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PUM2 recombinant protein (Accession Number: BC024218). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:114337(PUM2 Antibody) at dilution of 1:600
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Background
PUM2 (Human Pumilio homology protein 2), a member of the PUF protein family, binds to 3′ untranslated regions (3′ UTRs) of mRNA and to repress gene expression by controlling cytoplasmic polyadenylation and affecting mRNA translation [PMID:12459267]. When translationally dormant, PUM2, CPEB (CPE-binding protein) and Maskin form a complex on maternal cyclin B1 mRNA, precluding the formation of the active translation initiation complex [PMID:15687499]. PUM2 has been found to play a role in the mammalian nervous system, in particular in regulating morphology, arborization and excitability of neuronal dendrites [PMID:22016787].
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