PTPRJ antibody

PTPRJ antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PTPRJ Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, Jurkat cells, multi-cells/tissue. Observed molecular weight by Western-blot: 146-170kd

ELISA, WB

Human; other species not tested.

CD148 antibody; Density enhanced phosphatase 1 antibody; DEP 1 antibody; DEP1 antibody; HPTP eta antibody; HPTPeta antibody; PTPRJ antibody; R PTP ETA antibody; R PTP J antibody; SCC1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_002843). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PTPRJ, also named as CD148 and DEP1, belongs to the protein-tyrosine phosphatase family and Receptor class 3 subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRJ may contribute to the mechanism of contact inhibition of cell growth. PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). It was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction. The antibody is specific to PTPRJ.

• Casagrande S, Ruf M, Rechsteiner M. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. The Journal of pathology. 229(4):525-34. 2013.