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PTPMT1 antibody

Cat.#: 114314

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Product Information

  • Product Name
    PTPMT1 antibody
  • Documents
  • Description
    PTPMT1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer. Positive WB detected in mouse pancreas tissue. Observed molecular weight by Western-blot: 21-23kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    PTPMT1 antibody; PLIP antibody; PTEN like phosphatase antibody; DUSP23 antibody; MOSP antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PTPMT1 recombinant protein (Accession Number: NM_175732). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with Catalog No:114314(PTPMT1 antibody) at dilution of 1:300

    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with Catalog No:114314(PTPMT1 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:114314(PTPMT1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:114314(PTPMT1 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    PTPMT1, also named as MOSP and PLIP, is a Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PTPMT1 has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. It is a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase, resulted in developmental arrest and postimplantation lethality.
  • References
    • Shen J, Liu X, Yu WM. A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Molecular and cellular biology. 31(24):4902-16. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"